Numerical stuff for LR first.
Single family,
E(NCP) = n•q2/e2/4
if we take the comparison of QTL allele ~q2 as a variable, then ~q2/q2 follows a χ2 distribution with 1 degree of freedom.
Then the power = ∫Pχ2(1)•[1-Fcdf(threshold, df1, df2, c•χ2(1))] dχ2(1).
where, c = E(NCP)
Above obtained very good results for single families.
It is easy to consider multiple families like this:
E(NCP) = Σ(c•~q2i/q2) = c•(Σ~q2i/q2) = c•χ2(nf)
where nf is the number of families.
The theoretical results turned out much larger than empirical results.
To explore the source of difference, I calculated some results as below:
nf: 2
n: 30
df1: =nf
df2: =nf•(n-2)
q2: .2
h2: .4
Then:
ENCP=3.53
Ev
To be continued ....
Thursday, December 09, 2004
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1 comment:
Anyway, the integration about multiple families is no good. I am checking it if I can solve this problem today.
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